Molecular Formula | C45H63N13O12S2 |
Molar Mass | 1042.19 |
Density | 1.320±0.06 g/cm3(Predicted) |
Boling Point | 1616.2±65.0 °C(Predicted) |
Flash Point | 931.3°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 9.90±0.15(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.582 |
Physical and Chemical Properties | Artificial synthesis of vasopressin-like substances, the 8-position arginine into ornithine, and the effect of benseri vasopressin is similar, but the vasoconstrictive effect is stronger, more rapid, intravenous injection of 3min is effective, can be maintained for more than 1H. In addition, it can increase the arterial pressure without the side effects of catecholamines. It can also prolong the action time of local anesthetics. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.96 ml | 4.798 ml | 9.595 ml |
5 mM | 0.192 ml | 0.96 ml | 1.919 ml |
10 mM | 0.096 ml | 0.48 ml | 0.96 ml |
5 mM | 0.019 ml | 0.096 ml | 0.192 ml |
clinical application | ornithine vasopressin acetate can be clinically used for hemostasis in various surgical operations and can be used simultaneously with halothane. Ornithine acetate vasopressin in the treatment of decompensated hepatorenal syndrome in cirrhosis-acting on renal hemodynamics and atrial natriuretic factor. Compared with the natural arginine vasopressin (8-arginine-vasopressin), ornithine acetate vasopressin has weaker stimulation and diuretic effects of small intestinal smooth muscle, while vasoconstriction is stronger. Therefore, the addition of ornithine acetate vasopressin in local anesthesia can be used to reduce intraoperative blood loss and prolong the action time of local anesthetics, and there is no disadvantage that the addition of catecholamine drugs causes a decrease in oxygen tension, and does not cause delay in wound healing. |
biological activity | Ornipressin is an effective vasoconstrictor, hemostatic and kidney drug. |
use | clinically, it can be used for hemostasis in various surgical operations and can be used simultaneously with halothane. |